I've been missing out for a long time.' Then Dave has introduced another person to the metal community and it becomes like that shampoo commercial where they tell two friends and so on and so on. They are going to listen to that and think, 'I like that one song,' and they are going to get the record and listen to the rest of the album and go, 'Man, I love this style of music. I think it also opens up a door to a lot of people who just don't like metal. "We also have the super-heavy stuff on there," Mustaine continued, "and I think that is good because it really shows them everything we are capable of. He explained to Classic Rock Revisited: "Here's the thing… It is the first track for our new record label, which is a major label, they love the band and we showed them that, not only can we write commercial metal pop songs that people can't do anymore, because their either afraid, or they sound like they are hacking up a chicken bone they just don't know how to do it." However Mustaine purposely penned it as a radio-friendly track. Some fans criticised this song, claiming it was too poppy. Because the whole theory of the super collider is atoms swirling into one another at millions of miles an hour, I guess." And this first song is kind of, like, a song about no matter how bad things get, come with me, we'll take the high road and we'll hang out and have a great time and we'll stick together until the end of the world, so to speak, when the world explodes like a Super Collider. "And I thought, knowing how closed-minded people are with my faith and thinking that that's gonna change who I am as a person - which it did - and that that would also correlate into changing my guitar playing, which it didn't, I didn't wanna have a song called 'God Particle', because every village has its idiots, and unfortunately for me, a bunch of them follow me on the Internet. "Actually, the stuff's called the 'God particle.'" He continued. And I thought, 'Wow, that's a really cool story.'" The band consists of Thom Yorke (lead vocals, guitar, piano), Jonny Greenwood (lead guitar, keyboards, other instruments), Colin Greenwood (bass), Phil Selway (drums, percussion) and Ed OBrien (guitar, backing vocals). And there was a story in there about how they finally had identified the mass that goes around the molecules and stuff it's called the Higgs Boson and we had done that with the Super Collider. Radiohead are an English rock band from Abingdon, Oxfordshire, formed in 1985. I'm not really down with a lot of the viewpoints of the newspaper, but I kind of got used to reading it because of the puzzles in it - 'cause I love word puzzles I like to enrich my word power. He stated: "I was up in Santa Barbara, and USA Today, as a newspaper, I started reading a long time ago because it had Sudoku in it. And then the song ' Use The Man.'"ĭuring an interview with the Shockwaves HardRadio podcast, Mustaine explained that the song drew some inspiration from the search for the Higgs boson at CERN and particle colliders, but is mostly about hanging out and taking the proverbial high road until the end of the world. It happened with ' In My Darkest Hour.' I sat down and I wrote that all in one fell swoop. And this was one of those songs that when it was done it was kind of like, 'Oh, wow, it's done.' That's only happened a couple other times in my career. "And, you know, sometimes when you're writing a song, you know, you find yourself having to scratch your head and come up with parts and stuff like that. I was really excited about it," added Mustaine. to complete the song, and before you knew it, the song was done." "That song itself is a little bit of an older chord progression," he said, "and I was listening through some old riffs from a while ago and found that song, added a couple of little pieces to it to make it. Frontman Dave Mustaine explained the origins of the song to Jack Mehoff of the Colorado Springs, Colorado radio station 94.3 KILO. Supercollider / Butcher 12' Single, CD Single Radiohead Format: Vinyl 54 ratings See all 3 formats and editions Streaming Unlimited MP3 2. IPad 3, iPad 4, iPad Air, iPad iPad, iPad Mini 2, iPad Mini 3, iPad Mini 4, 9.The title track of Megadeth's fourteenth studio album premiered exclusively on the Full Metal Jackie radio show, and was released on Apon iTunes. IPhone 12 Pro Max, iPhone 13 Pro Max, iPhone 14 Plus: 1284x2778 IPhone Xs Max, iPhone 11 Pro Max: 1242x2688 IPhone X, iPhone Xs, iPhone 11 Pro: 1125x2436 IPhone 6 plus, iPhone 6s plus, iPhone 7 plus, iPhone 8 plus: 1242x2208 IPhone 6, iPhone 6s, iPhone 7, iPhone 8: 750x1334 IPhone 5, iPhone 5s, iPhone 5c, iPhone SE: 640x1136 IPhone: iPhone 2G, iPhone 3G, iPhone 3GS: 320x480
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Join Facebook to connect with Tyler Lacoma and others you may know. Preceding him in death was a niece, Meghan Seuferer. View the profiles of people named Tyler Lacoma. He is survived by his parents, Leo and Marie Seuferer wife, Kristi Seuferer son, Travis Bell brothers, Jeff (Pam) Seuferer and David (Lisa) Seuferer nieces and nephews: Tyler Seuferer, Haley (Cody Mikesell) Seuferer, Alarick Seuferer, Amelia Seuferer, Carlie Seuferer, and Ethan Seuferer along with many relatives and friends. He was a wonderful uncle to his seven nieces and nephews. He was very family oriented, giving, and loved to help people. When I walked into a room to audition, I knew they needed the triple. Ed loved spending time with Kristi and her son, Travis. Initially, her undiagnosed bipolar disorder was an asset. The couple made their home together near Lacona. On 11-11-11, Ed was united in marriage to Kristi Shields. It was built in 1979 and was last sold in 2013. He also LOVED to drive his Hamm's Blue 1972 Monte Carlo. 22937 Tyler St, a single family home located in Lacona, IA has 4 beds, 2 baths, and is 1,026 square feet. Camping, hunting, building big bonfires, and golfing were some of his favorite pastimes. Ed really enjoyed spending time outdoors. He then worked at Tension Envelope for 31 years while living in Altoona 18 years, before moving back to Lacona. Upon completion, he worked at the Lacona Co-op. After graduating from Southeast Warren, Ed attended Wichita Automotive Institute in Wichita, Kansas. Ed graduated with the SE Warren High School class of 1978. He was raised alongside his brothers, Jeff and David, in Lacona, Iowa. This home is currently off market- it last sold on Novemfor 260,000. About This Home 22054 Tyler St is a property on a 2 acre lot. Edward Leo Seuferer was born Decemto Elma Marie and Leo Edward Seuferer in Des Moines, Iowa. 22054 Tyler St, Lacona, IA50139 Redfin Estimate Beds Baths Sq Ft Off Market This home last sold for 260,000 on Nov 22, 2021. View more property details, sales history and Zestimate data on Zillow. Memorials may be made to the family to be designated at a later date. 0 Tyler St, Lacona, IA 50139 is a vacant lot listed for-sale at 196,375. Interment will take place at Newbern Cemetery. Family will receive friends on Friday, from 5:00 until 8:00 p.m., at the funeral home. at the Pierschbacher Funeral Home in Chariton. Services will be held Saturday, Jat 10:00 a.m. Ed Seuferer, of rural Lacona, passed away Jat the age of 58. This proposed rule would make certain amendments to part 802 as a result of the ongoing evaluation of military installations by the Department of Defense. Department of Defense based upon an evaluation of national security considerations, and that the Department of Defense will continue on an ongoing basis to assess its military installations and the geographic scope set under the rules to ensure appropriate application in light of national security considerations. The preamble to the final rule establishing part 802 noted that the military installations listed in the appendix were determined by the U.S. Section 802.227 sets forth the category descriptions of military installations identified in Appendix A. The specific military installations are listed in appendix A by name and location. The final rule establishing part 802 (see 85 FR 3158) identifies a subset of military installations around which certain real estate transactions are covered under CFIUS jurisdiction. The regulations at part 802 to title 31 of the Code of Federal Regulations (part 802) implement the provisions in section 721 of the Defense Production Act of 1950, as amended (DPA), and establish the process and procedures of the Committee on Foreign Investment in the United States (CFIUS) with respect to reviewing transactions involving the purchase or lease by, or concession to, a foreign person of certain real estate in the United States. Department of the Treasury, 1500 Pennsylvania Avenue NW, Washington, DC 20220 telephone: (202) 622–3425 End Further Info End Preamble Start Supplemental Information SUPPLEMENTARY INFORMATION: Sharma, Deputy Director of Investment Security Policy and International Relations or James Harris, Senior Policy Advisor, at U.S. Start Further Info FOR FURTHER INFORMATION CONTACT: You should only submit information that you wish to make publicly available. All comments received, including attachments and other supporting material, will be part of the public record and subject to public disclosure. Without change, including any business or personal information provided, such as names, addresses, email addresses, or telephone numbers. In general, the Treasury Department will post all comments to Please submit comments only and include your name and company name (if any) and cite “Provisions Pertaining to Certain Transactions by Foreign Persons Involving Real Estate in the United States” in all correspondence. We encourage comments to be submitted via Department of the Treasury, Attention: Meena Sharma, Deputy Director of Investment Security Policy and International Relations, 1500 Pennsylvania Avenue NW, Washington, DC 20220. Written comments may be submitted through one of two methods:Ĭomments may be submitted electronically through the Federal government eRulemaking portal atĮlectronic submission of comments allows the commenter maximum time to prepare and submit a comment, ensures timely receipt, and enables the Treasury Department to make the comments available to the public. Written comments must be received by June 5, 2023. Specifically, the rule would add eight military installations to the appendix and make corresponding revisions to the definition of the term “military installation.” DATES: The rule would amend the regulations that implement the provisions relating to real estate transactions pursuant to section 721 of the Defense Production Act of 1950, as amended. Office of Investment Security, Department of the Treasury. Provide legal notice to the public or judicial notice to the courts. Rendition of the daily Federal Register on does not Until the ACFR grants it official status, the XML Legal research should verify their results against an official edition of The official SGML-based PDF version on, those relying on it for The material on is accurately displayed, consistent with While every effort has been made to ensure that Regulatory information on with the objective ofĮstablishing the XML-based Federal Register as an ACFR-sanctioned The OFR/GPO partnership is committed to presenting accurate and reliable Register (ACFR) issues a regulation granting it official legal status.įor complete information about, and access to, our official publications Informational resource until the Administrative Committee of the Federal This prototype edition of theĭaily Federal Register on will remain an unofficial Each document posted on the site includes a link to theĬorresponding official PDF file on. The documents posted on this site are XML renditions of published Federal Register, and does not replace the official print version or the official It is not an official legal edition of the Federal This site displays a prototype of a “Web 2.0” version of the dailyįederal Register. Reception for the game was mostly positive. If they answer the question correctly, they gain that number of points, but if their answer is incorrect, they lose that number of points. The question appears onscreen, and the teams discreetly give their answer with the remote. Both teams then bet 5, 15, 30, or all of their points. The topic the final question will be about is displayed. Both teams try to name the musician or band the clues refer to. As in round three, it is the other team's turn when the answering team gives a wrong answer.įive words or phrases all referring to the same musician or band appear onscreen. Teams must take turns in this round when a team gets an answer wrong, or when a team gets a golden-frame question correct, it's the other team's turn.Ī series of events, song titles, or musicians' names are displayed, and the teams must be arranged smallest to largest or chronologically. When two photos with golden frames are placed side-by-side, that means that a correct answer to that question is worth five points. Players must identify which of the two shown musicians the trivia fact corresponds to. Photographs of two musicians appear side-by-side, with a trivia caption beneath them. The players must shout out what word is on the golden tile, which doesn't flip over until the end. Each correct answer is worth two points.Ī song's lyrics begin appearing on screen, on blue tiles. Unlike the first two rounds of game play, teams must take turns in Round Three when a team gets an answer wrong, it's the other team's turn. Snippets of five music videos for songs from Round One are shown six trivia facts appear on-screen, and the teams attempt to match the trivia facts to the corresponding music videos. Each correct answer earns one point.Īlbum covers comes together piece by piece the teams must try to shout out the name of the recording artist who released the albums. Round One: Name That SongĪ snippet of a song is played, and the teams must attempt to shout out the name of the song. The game consists of 8 rounds, played entirely using a TV remote. Two volumes of the game were later released in the UK, under the titles "Chart Toppers" and "Battle of the Bands." Gameplay Hasbro promoted the game, alongside Shout About TV, as among its releases for the 2005 holiday season. A Country Music edition of the game was also released, exclusively available at Wal-Mart. In a press release, Mark Blecher of Hasbro Games stated that "This latest portfolio of SHOUT ABOUT games - music, country music and TV - reflect today's high-energy, fast-paced gaming style, providing players with instant gratification and immediate play." Two volumes of the game were released on August 1, 2005. Shout About Music is a music DVD trivia game created by ODVD and distributed by Hasbro, released on August 1, 2005, as a follow-up to their line of " Shout About Movies" games. DVD music trivia game Shout About Music PublishersĮach volume of the DVD game includes three prearranged games unlike Scene It?, "Shout About" games' questions do not change every time the game is played. We’ve not yet worked out how to set the input color space for multiple clips simultaneously, so we have to go through and do them one by one. You can even use ACES Workflow if you wanted to.Įven on the desktop version of Resolve, you can’t set the input color space in the cut page, but you can do it in the color page. One of the things that we’re most impressed to see on the iPad is full color management. Playback was still fine, with was no stuttering or issues. To test this thing out, we set the resolution to UHD. Obviously, there are things that you can’t do on the iPad version yet like plug in an UltraStudio, but again, who knows? Maybe the dev team will add features like this in the future. Just the same as the desktop version, timeline settings are configured in project settings. That’s no mean feat and the interface is surprisingly intuitive on a touch interface. You might get sick of hearing us say that it’s the same as the desktop version – we’ve only been using Resolve on iPad for about two weeks now, but we’re still blown away by the fact that it looks and functions exactly like the desktop version of Resolve. You do not need this in order to be able to edit comfortably on the iPad. We just want to emphasize though the Speed Editor is an optional extra. Of course, once clips are in your timeline, you edit them the exact same way you would on a desktop version of Resolve, either using the pen, your finger, or alternatively, of course, you can trim them down with the Speed Editor. If you have a Speed Editor, yep, you can use that too. Importing Media into DaVinci Resolve for iPad Peripherals We can drag clips into the timeline or we can load them in the source viewer and create in and out points, and then bring them down into the timeline. The media used for this review is 6K ProRes 422 at 24 frames per second. It just links to the media wherever it’s stored. Resolve handles media exactly the same way as it does on the desktop version of Resolve. We’ll select all of the clips in this folder using the select all button and import them. The media that we’re using, we’ve got about 300 gigabytes of it, is located on the iPad. That includes attached SSDs, cloud services like Dropbox and iCloud, or even network drives. Resolve can access any media that you can see in files. There’s no media page yet in DaVinci Resolve for iPad, but we’re sure it’s coming.Ĭurrently, to import media, we’ll use the media pool in the cut page. Also, notice the Project Manager! Accessing Media Resolve for iPad currently includes the Cut & Color page. You’ll see it’s even possible to create additional local libraries, but we’re just going to work in the existing one and create a new project. We’ve got the same three tabs for connecting to local network or cloud databases. This will start to give you a sense of how fully featured the iPad app is. The only part of the desktop interface that is missing is the Menu Bar, usually visible at the top.Ĭurrently, Resolve on iPad only has the cut and color page. If you’re already used to using Resolve, then there’s next to no learning curve. You can use your finger or a pencil to navigate, it’s very intuitive. The first thing that you will notice is that it looks exactly like the desktop version of Resolve. Tested on 12.9-inch iPad Pro M2 by FEP trainer Leon Barnard Interfaceīy default, Resolve launches into the last project that you opened. Is this the full version of Resolve or is it limited? Is it good enough to do professional work with? How well does it run and what accessories do you need? If you’re interested in the answers of those questions, then please read on or watch the video below. See the full PDF Course Outline here.The beta of DaVinci Resolve is now on the iPad, and we’ve been using it for a few weeks. The main focus is for users transitioning from Apple Color, but this is absolutely suitable for any new user coming to DaVinci Resolve from other color grading tools. Not Just For Apple Color Users – Great for All Newcomers to Resolve Outputting is handled both directly with Resolve or through an XML/AAF workflow, which maintains total flexibility between the edit and the grade. In addition to the core color tools, you will see how to create complex secondary corrections in the most straightforward and time efficient way. Naturally, the majority of the course is spent in the grading area, where you explore the power and flexibility of Resolve’s nodal interface. You start with system configuration and the best ways to import projects from your NLE. The focus is on practical tips to get you working quickly and in the right way. “I designed the course I wish I had when I started”īen Brownlee, author of Creative Color Grading for Apple Color, presents these tutorials. She enjoys giving readers an honest idea of where to buy sustainable clothing that makes a difference in our environment. The right kind of pajama is more than just about being stylish. We have something for all kinds of occasions. To make this list, we deeply researched the market by reviewing certifications and user reviews, interviewing industry representatives, and evaluating manufacturers to find the most sustainable organic pajamas.Īuthor Amanda Ogle is a veteran reporter who loves writing about sustainability and believes it is important that we all strive to be as environmentally friendly as we can. Our range of summer pajamas, cotton pajamas, cozy pajamas, satin pajamas, flannel pajamas, thermal pajamas, nursing pajamas, maternity pajamas, plus-size pajamas and family pajamas are sure to keep you snug and comfy. You can also find products that use cotton that meets USDA Organic standards, like the clothing from Harvest & Mill.Īn additional organic certification that’s robust but less commonly seen in the United States is Soil Association Organic. 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And for more great quotes to include in a Mother's Day card or Instagram post, check out our Sweet Mother's Day Quotes Every Mom Should Read. A mother spending quality time outdoors with her daughter and taking a self-portrait in a city park edmonton, alberta, canada Happy Mothers Day funny greeting card with pink heart, vector illustration, lettering, text. If you're looking to encourage a new mom in your life, be sure to include one of these perfect gifts of first-time mamas. Get her a bouquet of her favorite flowers and include a note from some of culture's greats who honored the depth and grace of motherhood. So this Mother's Day as we make her breakfast in bed or an impressive brunch, shower her with gifts, and remind her how much she means to so many people, share with her some of these strong mom quotes to remind her of the unique power she holds as a mother. Moms are pros at making holidays extra special, taking an average Friday pizza night and making it a weekly family tradition, and they have an uncanny knack for always knowing where "that thing" is you can't seem to find. Just when we think our own moms have reached the capacity of their resourcefulness and grit, they pull out superpowers we didn't even know they had. Want even more Mother's Day fun? We all know that the way to anyone's heart is through their stomach, so why stop at dinner? Start her day off right with a Mother's Day brunch (complete with mimosas!) and don't forget about dessert after too.Being a mom is one of the toughest (and yet rewarding) jobs anyone can do. Don't forget-it's the thought that counts ( and doing the dishes after dinner too). Worried you're too much of a beginner in the kitchen? Don't stress-we've got tons of straight-forward, fool-proof recipes here, like our falafel stuffed peppers and our Mediterranean chicken. They're classic, but with little twists that make them extra special. mom mothers day happy mothers day evite super mom art baby mom mother working drink cheers mom mother mothers day kids mom parenting mommy motherhood mom emoji mother mama mothers day supermom petportrait. Looking for more of a casual Mother's Day meal that the whole family can enjoy? Try our boursin-baked ziti, our goddess bowls, or our chicken fajita marinade. season 2 foxtv wonder woman bless the harts super mom. Whether mom loves a cozy baked pasta or a creamy chicken dinner, or something a bit more on the fancy side like a lobster risotto or our steak au poivre soup, we've got plenty of recipe ideas sure to bring a happy tear to her eye. Homemade just is always more special than eating out, especially when it means you get to dodge all those crowded restaurants. Happy Mother’s Day, Mama Thank you for all your unconditional love through the years (including my terrible teens). There’s no one like you There’s no perfect mother, but you’re as close as they come. In celebration of her and everything she's done for you, w e gathered our 30 best Mother's Day dinners that'll make her feel ultra special. Happy Mother’s Day to the most incredible mom in the world. Moms are simply the best, so what better way to say "I love you, mom" (or "Mom, I need you to jump my car again") than with an impressive, delicious homemade Mother's Day dinner? After all, she's taken you to all your violin (and dance, and maybe even tuba) lessons, she's checked your homework, driven you to the mall, and likely made you all your favorite meals (from chicken soup when you were sick to cake on your birthday). Download this Super Mom, Happy, Mother, Day PNG clipart image with transparent background or PSD file for free. To date, John Wick: Chapter 4 is the second-best domestic opening of 2023, after Disney/Marvel Studio’s Ant-Man and the Wasp: Quantumania ($106.1M). John Wick: Chapter 4 is the biggest R-rated opening post-pandemic, exceeding Halloween Kills‘ $49.4M (which was hampered by a theatrical day-and-date release on streaming service Peacock). Of those nine franchises, only five have done what John Wick has accomplished in building to four films with each new offering exceeding the last (i.e., 4 greater than 3, 3 greater than 2, 2 greater than 1). These box office bombs demonstrate what Movieguide® has been emphasizing: moviegoers want to see family-friendly content with a strong moral message.- John Wick joins a select few film series that set a franchise record with their fourth outing, only nine in the past 40 years. BABYLON also contains two vomit-inducing scatological scenes, brief extreme violence and politically correct attacks on morality and decency. Even when the movie creates a moving homage to the Golden Age of Hollywood, the sequence goes on too long. It has more than 200 obscenities and profanities and many lewd, explicit images, especially in the big party scene that seems to last forever. There were many reasons why BABYLON ultimately failed, from its lengthy runtime (3 hours and 9 minutes), its over-inflated budget, and the raunchy content in the movie.Ĭlocking in at more than three hours. LIGHTYEAR also taints the TOY STORY franchise, because it says the politically correct movie became Andy’s favorite movie.Īnother major flop was BABYLON, the follow-up movie from LA LA LAND’s Damien Chazelle. Thus, the whole movie becomes a validation of LGBT ideology and an attack on masculinity and the biblical view of family. Eventually, it’s her life that inspires Buzz, her granddaughter and everyone else. His lesbian friend, Alisha, is the real hero. However, Buzz isn’t really the hero of this story. LIGHTYEAR constantly places obstacles in Buzz’s way. TOY STORY fans had plenty of issues with the spin-off, from the exclusion of Tim Allen, who originally voiced the character, to LGBT+ plotlines.Ī portion of the Movieguide® review reads : STRANGE WORLD has a politically correct, unscientific attitude against “fossil fuels.” Also, the characters discover that their world rests on the shell of a giant tortoise.ĭisney had another bomb with LIGHTYEAR. For example, the teenage grandson flirts with another boy. Though it has some pro-family values that extol forgiveness, they’re spoiled by an unapologetic, politically correct homosexual agenda. STRANGE WORLD is beautifully animated, but it has a boring script and underdeveloped characters. Movieguide®’s review of STRANGE WORLD reads : Some blamed STRANGE WORLD’s stale plot, while others pointed to its content. The movie followed a family of explorers traveling through a new land, but moviegoers were not fans. Last year, 2022, was full of big movies, but there were also plenty of bombs.ĭeadline recently released its list of last year’s biggest box office flops, and many of the movies listed reflect the audience’s dislike of immoral content.ĭisney’s STRANGE WORLD lost $197.4 million at the box office. Published: ApScreenshot from Pixar YouTubeĢ022’s Biggest Box Office Flops Prove Audiences Want Movies With Strong Moral Messages If you’re lucky enough to be alive, you turn into an old person with every day you live. It’s wonderful to see people my age on the screen and not have the elders be jokes or punch lines. It’s wonderful to see people my age on the screen and not have the story be about dementia or dying. They have joys and sorrows, they cherish human contact, and they can love mightily. The big deal is these two older humans are as vital and alive as anyone of any age. Whether the joints are getting creaky isn’t the issue. Maybe there were three strong men hidden behind the camera who helped them up and down for these scenes – I would need that. I was impressed to see them sitting on the floor with Jamie or sleeping on the ground in a tent. I’m at the same stage in life as Fonda and Redford. Watching Fonda and Redford inch toward each other is the chief attraction. They find a way to connect their souls at night. But they find a way to make it work, despite what life throws at them. It isn’t the ending I wanted, with Addie and Louis sharing a peaceful domestic life together. And, they continue to share a bed.Īddie and Louis head to Denver for a weekend in a nice hotel. Louis teaches Jamie how to throw a baseball. Louis lets him play with an old electric train. Having Addie’s grandson Jamie (Iain Armitage) around brings Addie and Louis even closer. Gene’s wife left them and he’s lost his business, so Grandma must step up while he pulls it together. Addie’s son Gene (Matthias Schoenaerts) comes by and leaves his son behind. Louis’ daughter Holly (Judy Greer) pays a visit. They decide they might as well go public and head out for Sunday lunch so everyone can get a good look at them together.Īs parents, both of them have damaged children. Addie’s friend Ruth (Phyllis Somerville) knows all about it before Addie tells her. Louis’ coffee buddies at the cafe, lead by an obnoxious Dorlan (Bruce Dern), tease him in stupid ways. They talk about their regrets, their failures, their joys, their sorrows.Įveryone in their small Colorado town knows Louis is walking over to Addie’s house every night. They don’t touch or cuddle, they sleep side by side. He thinks about it – nothing happens fast at their age – and a couple of nights later they begin sleeping together.įor weeks that’s all they do: sleep. That changes the night Addie knocks on Louis’ door and tells him she can’t sleep. Louis Waters (Redford) and Addie Moore (Fonda) know the externals of each other lives. When Louis narrates his past affair that almost ended his marriage, he does not seem sorrowful but almost okay with how things turned out, as if it were inevitable.Our Souls at Night stars Jane Fonda and Robert Redford in a quiet story about a pair of elders who have been neighbors for years. So are the most neighbors who eye Louis when he leaves in the morning from Addie’s place. Addie and Louis are both relatable, and so are their kids who are pretty shocked at their romance. The best thing about this book is the characterization. This happens to be one of them." love this! "There are a few books that take you deep into their world and detach you from reality. They look at it with a sense of being at peace with whatever has come to pass and show hope for the future that holds good things, if not the best. You would expect a book like this to be melancholy, but it truly is not even though often they reminisce their past which has not been the best. What follows is their nights together when they sleep, talk and reflect upon the past. Sleeping together in the companionship of old age seems like a perfect fit for both of them. True, lonely have they both been after the demise of their respective spouses. A +1444 C>T polymorphism in the CRP gene has been associated with differences in CRP concentration. These results suggest that CRP, although not an initiating insult in ARDS, may contribute to the subsequent abnormalities of surfactant function and thus the pathogenesis of the pulmonary dysfunction seen in ARDS.« lessĬ-reactive protein (+1444 C>T) polymorphism influences CRP response following a moderate inflammatory stimulus.ĭ'Aiuto, Francesco Casas, Juan P Shah, Tina Humphries, Steve E Hingorani, Aroon D Tonetti, Maurizio SĮlevations in C-reactive protein ( CRP) concentration are associated with an increased risk of future coronary events in prospective studies and it has been suggested that CRP could be used to aid risk prediction. In contrast, human serum albumin (HSA) at 500 and 900 micrograms/ml had no inhibitory effect on Surfactant TA surface activity. Furthermore, the surface activity of a clinically used surfactant replacement, Surfactant TA (2 mg/ml), was also severely impaired by CRP in a dose-dependent manner (doses used ranging from 24.5 to 1,175 micrograms/ml). As a result of this interaction, CRP inhibits the surface activity of a PG-DPPC mixture when tested with a Wilhelmy surfactometer or with the Enhorning pulsating bubble apparatus. Our results show that CRP binds to liposomes containing DPPC and phosphatidylglycerol (PG). 4.04more » +/- 2.2 micrograms/mg total protein in normals). Our results showed that CRP levels in the bronchoalveolar fluid (BALF) was increased in patients with ARDS (97.8 +/- 84.2 micrograms/mg total protein vs. The structural homology between PC and the major phospholipid component of surfactant, dipalmitoyl phosphatidylcholine (DPPC), led to the present study in which we examined if CRP levels might be increased in patients with adult respiratory distress syndrome (ARDS), and subsequently interfere with surfactant function. CRP binds to phosphorylcholine (PC) in a calcium-ion dependent manner. Plasma levels of the acute-phase reactant, C-reactive protein ( CRP), increase up to one thousand-fold as a result of trauma or inflammation. Impact of C-reactive protein ( CRP) on surfactant function This might constitute another level of complement regulation, which has implications for systemic lupus erythematosus where CRP is often low despite flare-ups.« less We propose that the underlying mechanism depends on fluid-phase interaction between C1q and CRP. Using radial immunodiffusion, CRP-C1q interaction was observed in serum samples with high CRP concentrations. Unexpectedly, the activation was efficientlymore » down-regulated at CRP levels >150 mg/L. The binding of serum CRP to PC-KLH dose-dependently triggered activation of the classical pathway. The total serum protein deposition was quantified and deposition of IgG, C1q, C3 c, C4, factor H, and CRP detected with polyclonal antibodies. A low- CRP serum with different amounts of added CRP was exposed to the PC-surfaces. PC conjugated with keyhole limpet hemocyanin (PC-KLH) was immobilized to cross-linked fibrinogen. The aim was to characterize CRP-induced complement activation by ellipsometry. Sjoewall, Christopher Wetteroe, Jonas Bengtsson, TorbjoernĬ-reactive protein ( CRP) interacts with phosphorylcholine (PC), Fc receptors, complement factor C1q and cell nuclear constituents, yet its biological roles are insufficiently understood. Solid-phase classical complement activation by C-reactive protein ( CRP) is inhibited by fluid-phase CRP-C1q interactionĭOE Office of Scientific and Technical Information (OSTI.GOV) |
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